Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose

Abstract

Objectives

This clinical, analytical, retro-prospective, auto-controlled, not randomized, and not blinded study, aimed to investigate the association of changes in the serum glucose levels with the pre-and-post changes in the size tumor in mm³ in the Non-Functional pituitary adenomas.

Methods

Pre-and post-surgical MRI, as well as the measurements in the serum glucose levels and immunohistochemical techniques were performed in all the patients in the study, with a mean followed-up until 208.57 days. A comparison was made between the reductions in tumor size of hormonally active pituitary adenomas (HSPAs) vs NFPAs.

Results

Seventy-four patients were included in this study, of whom, 46 were NFPAs. The decrease in the NFPAs tumor size after surgery was statistically significant (P ≤ 0.0001). The Mean of the differences of both type of tumors in mm³ were −9552 ± 10287. Pre-surgery, the mean of the HSPAs were 8.923 ± 2.078; and the NFPAs were 14.161 ± 1.912. The differences in the tumor size were statistically significant (p = 0.039). Post-surgical, the mean of the HSPAs were 2.079 ± 971, with a (p = 0.14): and the NFPAs were 4.609 ± 1.205. After surgery of the NFPAs, most of the patients-maintained serum levels ≤ 100 mg/dL, with a statistical significance (P ≤ 0.0003).

Conclusion

This study demonstrates for the first time the correlation between the presence of pre-and post- surgical changes in the NFPAs, with modifications in the levels of serum glucose, and the comparison, pre- and post-surgical between the tumor size of HSPAs and NFPAs.

Keywords:

• Non-functional pituitary adenoma
• magnetic resonance image
• serum glucose levels
• pituitary surgery
• hormonally active pituitary adenomas

Disclosure statement

The authors report there are no competing interests to declare.

Ethics statement

The study involved human participants, in which each of one, recieved a written informed consent. It was reviewed and approved by the Medical Ethical Committee of the General Hospital of Mexico (‘Dr. Eduardo Liceaga,’ Mexico City, Mexico) with the folio number DI/20/403/03/87, in accordance with the latest version of the Declaration of Helsinki, as well as the national data protection regulations.

Data availability statement

The data that support the findings of this study are available on request from the corresponding author, [Carrillo-Ruiz, J.D]. The data are not publicly available due to their containing information that could compromise the privacy of research participants.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.