ABSTRACT
Objectives
This study aims to examine whether the genetic variants in the genes for Granzyme B (GZMB) and Interferon Induced with Helicase C domain 1 (IFIH1) were associated with psoriasis.
Background
Psoriasis, a papulosquamous skin disease, was initially thought of as a disorder primarily of epidermal keratinocytes but is now recognized as one of the most common immune-mediated disorders. It is caused by the interplay between multiple genetic and environmental risk factors.
Subjects and methods
This case-control study has 65 participants with psoriasis and 65 healthy controls. Real-time PCR was used to genotype GZMB (rs8192917) and IFIH1 (rs35667974).
Results
Genotype occurrence and allelic spreading for both SNPs are in Hardy – Weinberg equilibrium. The genotype and allele distributions of rs35667974 showed no differences between the studied groups. Regarding rs8192917, compared to Group II, there is a statistically significant rise in the CC genotype and C allele in Group I. Higher PASI scores are detected in the C/C and C/T genotypes more than the T/T genotype. Univariate and multivariate analyses revealed that BMI, catalase, MDA, and rs8192917 (C/C) are associated with psoriasis.
Conclusion
GZMB rs8192917 was significantly related to psoriasis risk; its C allele is likewise associated with psoriasis vulnerability. However, our investigation found no link between rs35667974 and psoriasis.
KEYWORDS:
Disclosure statement
No potential conflict of interest was reported by the author(s).
Authors’ contribution statement
Sara Kamal Rizk: conceptualization (lead), writing – original draft, visualization, and investigation. Azza Gaber: review and editing, formal analysis, and visualization. Samah El-Ghlban: review and editing (equal), and visualization. Israa Salah Eldin: methodology, writing – review and editing (equal).
Data sharing statement
Data is available upon reasonable request from the corresponding author.