Mental health care for trans and gender diverse youth from culturally and linguistically diverse (CALD) backgrounds: Reflections from communities of practice

Abstract

Introduction

Trans and gender diverse youth from culturally and linguistically diverse (CALD) backgrounds are at increased risk of experiencing poor mental health outcomes, including suicidal crisis. The aim of this clinical perspective paper is to discuss considerations from mental health practitioners and identify practical actions for enhancing mental health care delivery and reduce suicidality.

Method

This paper is created based on the exchange of experiences of mental health workers in CAMHS. A Community of Practice (CoP) design was used to facilitate the identification of practical actions based on the health workers’ experience. The content of these discussions was summarized in six main areas for action.

Results

The strategies included: accounting for the effects of trauma in engaging the young person; cultivating active open listening and encouraging culturally meaningful expressions of distress; discussion and co-decision making around risk with the young person; promoting choice and flexibility; and identifying supports within and beyond the family system.

Conclusion

The recommendations are substantiated by current findings in multicultural mental health including idioms of distress, person-centred care, and barriers to accessing mental health services by gender and ethnic minority youth. Further implications for clinical practice are discussed.

Keywords:

• Transgender youth
• gender diversity
• Child and Adolescent Mental Health Services
• suicide prevention
• culturally and linguistically diverse youth

Background

There is a steadily accumulating literature indicating that trans and gender-diverse youth are at increased risk of poor mental health outcomes, including emotional distress, depression, anxiety, and substance use (Hawke et al., 2021; Reisner et al., 2015). These circumstances are made worse when gender diverse youth experience peer victimization, non-acceptance from family members, and interpersonal violence (Haas et al., 2014). Although estimates vary, gender-diverse youth are at higher risk of experiencing suicide ideation and suicide-related behavior (Reisner et al., 2015; Wiepjes et al., 2020). A recent data analysis from 6,327 gender-diverse service users in the U.S. highlighted suicide attempts were seven times higher for people aged 18 or less when compared to those aged over 45 years (Mak et al., 2020).

At the same time gender diverse youth engagement with specialized mental health services demonstrates less than 10% of the referrals for this population were from ethnic-minority youths (de Graaf et al., 2019), and higher risk for suicide-related behavior has been identified among ethnically diverse sexual minority youth when compared to White sexual minority youth (Baiden et al., 2020). Barriers to accessing care include discrimination, anticipating uncomfortable experiences and consequences, and the need to educate providers with limited knowledge on gender diversity (Lerner & Robles, 2017).

The final Report from the House Select Committee on Mental Health and Suicide Prevention (Commonwealth of Australia, 2021) recommends a clear future focus on groups that are disproportionately affected by suicide, including young people, members of the LGBTIQ + community, and people from culturally and linguistically diverse (CALD) backgrounds (Commonwealth of Australia, 2021). Potential drivers of distress include emerging self-identity, suppressing sexuality, bullying, discrimination, isolation from peers, body image concerns, and navigating one’s culture of origin and adapting to new social norms in Australia. Education for health care providers around trans and gender diverse health is paramount (Paradiso & Lally, 2018).

Design

The present clinical perspective paper is authored by and reflects clinician-led thinking discussed and considered during a Community of Practices (CoP) project. The CoP consisted of regular meetings in which clinicians from professional backgrounds of mental health nursing, social work and psychology came together to exchange experiences and discuss solutions to common areas of concern (Pyrko, Dorfler, & Eden, 2017). In the mental health care sector, CoP can facilitate the identification of practical actions based on health workers’ “ground experience,” aiming at enhancing quality of care (Poole & Bopp, 2021; Macedo et al., 2022). The periodic discussions between participants creates a system of collective cognition, promoting deep understanding of topics and refinement of the problem-solving strategies identified (Pyrko et al., 2017). The interaction between workers can also promote valuable exchange of professional skills, validation of experience, and building up professional resilience (Delgado et al., 2021). CoP’s have been fostered by state-level Health Networks in South Australia aiming at providing leadership and clinical service development across specialty areas of healthcare (SA Health, 2023). This series of CoP meetings at the centre of this paper explored challenges, strengths and strategies associated with supporting trans and gender diverse CALD youth experiencing mental health and suicidal distress presenting to public sector i.e., Child and Adolescent Mental Health Services - CAMHS.

The participants of the CoP events have authored this paper. As a clinical perspective paper, the discussions and recommendations herein represent the perspective of the authors on recommended practice for supporting trans and gender diverse CALD young people. The initiative was established and co-facilitated by the second and seventh authors as a partnership between the University of South Australia Mental Health and Suicide Prevention Research and Education Group and mental health professionals working in CAMHS.

Methods

The CoP meetings occurred monthly between September 2021 and May 2022. Potential participants were approached by online invitation. The central focus of the CoP meetings was on understanding and responding to mental health and suicide related distress experiences of trans and gender diverse youth from CALD backgrounds. The online invitation circulated among practitioners was for a free professional development opportunity for government and non-government mental health workers led by the University of South Australia. No inclusion criteria were specified for participation. The invitation resulted in the engagement of five practitioners (authors 2-6) with a minimum of four and maximum of 27 years of clinical experience in mental health care delivery.

A total of seven meetings occurred through the secure Zoom platform in between September 2021 and July 2022. The discussions focused on identifying challenges perceived in mental health care delivery for trans and gender diverse CALD youth in mental health and suicidal crisis, aiming at formulating practical recommendations for mental health workers’ responding to suicidal distress. Meetings one and two were used to develop suggestions. The first practical actions identified by the workers in the CoP meetings were summarized by the first and seventh authors and reviewed in meetings three and four. It is noteworthy that the first, second and seventh authors have doctoral degrees. The seventh author is a senior researcher and academic professor with over 300 published research outputs in the areas of mental health and suicide prevention. Based on the cumulative elements of the CoP discussion across all meetings, an emerging set of recommendations were proposed and discussed by the first and seventh authors in meeting five.

Recommendations arising from this CoP were thus developed through an interactive and iterative process based on the first-hand experience of mental health professionals working with trans and gender diverse CALD youth. The practical recommendations were reviewed and critiqued by a subject matter expert independent to CoP participants prior to meeting six. A final version was subsequently discussed and agreed by all CoP participants in meetings six and seven. The participants agreed to submit the recommendations for this publication at the start of the CoP meetings.

Findings and discussion

The intersectionality between gender diversity and ethnicity was raised by the CoP participants as a key-point in increasing risk of suicide-related behavior among trans and gender diverse young people from CALD backgrounds. Besides issues related to gender identity exploration, individuals may experience significant additional stressors, and these may be cumulative and compounding for mental health as they intersect with identity and relationships that span cultural, social, peer, school, friendship groups and related aspects of intersectionality. A summary of the main challenges perceived by clinicians are presented in the next section. Where relevant, recommendations are referenced by findings in multicultural mental health. Table 1 summarizes actions to support trans and gender diverse youth from CALD backgrounds in mental health and suicide related distress.

Table 1. Practical actions to support trans and gender diverse CALD youth in mental health and suicidal distress.

Trust and rapport	Allow for time to build trust and rapport; Due to fear of rejection and ostracizing, trans and gender diverse CALD youth need time to reduce their perception of risk and feel safe. Work to create a psychologically safe space for youth to tell their story as a strategy for trust and rapport. Explore contact with services and acknowledge the young person’s feelings of unfamiliarity and uncertainty. Communicate that you can discuss and make a shared decisions on what can be discussed with family or other professionals. Start a conversation on knowing and respecting preferred names and pronouns. Decide with the young person which names and pronouns to use to encourage agency, decision-making and psychological safety. Consider the need to communicate specificities of name and pronouns use to service administrative and reception staff. Advise non-clinical staff that some family members may be unaware of the young person’s gender identity and use of personal pronouns. Prioritize – whenever safe and possible to do so - care delivery in the absence of an interpreter. This may be necessary to create safety for the young person to trust and engage with the service, their right to privacy and safety in the community.
Strategies to reduce inequality	Unpacking the young person’s experience and taking the time to listen is a therapeutical strategy per se. The clinician might be the first person to whom the young person is disclosing their distress. “Bearing witness” means to move beyond the need to interpret the young person’s experience based on the practitioner’s own point of reference, as a form of active open listening. “Bearing witness” is also a way to reduce the power imbalance in the therapeutic relationship as the practitioner becomes aware of their own potential biases and leans in to listen to the young person’s experience. Cultivate “open curiosity” about the young person’s experience of their own gender. Explore meaning(s) attributed to identifying as trans or gender diverse. Acknowledge the implicit risk of stigmatizing the experience of patients by inflexibly adhering to protocols. Rigidity in how assessment and intervention is conducted by a practitioner or service can amplify feelings of inequality and stigma experienced by this group in varied contexts.
Encouraging culturally meaningful expression of distress	Show willingness to appreciate diverse understandings of mental health and suicidal distress. Mental health workers need to constantly reflect on the power dynamics associated with delivering care to populations of diverse backgrounds. Invite the young person to guide you in understanding their distress and what perspectives they bring into the conversation. Explore in a culturally meaningful way. Explore young person’s expectations around involvement with family and community and how much they feel included in their cultural context. Questions might include: What does your family expect of a young person such as yourself? What is the most difficult part in trying to participate in family life? What is the easiest part of it? It can be helpful to explore nuances of their experience from a culturally and linguistic-diverse perspective and the way they perceive the experience of peers from other backgrounds. Questions might include: What does your family believe [use the young person’s own/ preferred terminology] should be like? Is that different from what you see as the experience of your peers? Be conscious of words and actions to safely discuss concerns and strengths related to gender diversity. It is important to facilitate a conversation that is not characterized by the presence of forced choices; allow for the young person to decide how much they want to disclose. Understanding of distress may involve engagement between stakeholders, ways of knowing brought by each person and the diversity within and between understanding. Be open to new insights linked to cultural, religious, and spiritual concepts and explanatory models used when discussing gender diversity.
Promote flexibility, choice, shared decision making	Clarify limits to confidentiality, emphasizing psychological safety as a priority. Communicate it in a way that is encouraging of trust, power, and autonomy. Mental health workers communicate to the young person that they are not alone in their distress. Examples might include: “Generally, I would discuss it with you first if I am concerned about your safety. Then we can discuss who else we might need to talk to.” When assessing drivers of suicidal distress, be open to potential issues that might require priority attention. Although it can be a driver for suicidal distress, questions around gender identity might not be pressing for some young people. Involve the young person in deciding priorities, what to disclose to family members and what support is needed. Assess and facilitate options on disclosing sensitive information that can increase distress and subsequent risk. Acknowledge that suicide ideation/risk fluctuates. The young person may seek a personalized safety plan or crisis plan.
Engaging family in promoting safety	Explore cultural understanding of mental health distress and suicidal ideation; avoid clinical jargon and be open to other conceptualisations of health and wellbeing. Questions might Include: Within your family and community, how do people express their distress? What is acceptable, what is not? When people express their suffering, distress or struggles what they are expecting other people’s response to be? If you were in your home country, what supports would you have/who could you turn to in case you needed help? Identify caregiver’s concerns and validate distress What are your major concerns for your child? When did you first start being concerned? It sounds like you might be scared about what can happen to your child. As a parent, what is important to you for your child? Engage a future-oriented discussion around wellbeing. Questions might Include: What sort of support do you think you can provide for your child at present? What can you do to promote your child’s safety at this time? What supports would you need to increase their safety? What life has been like for you since you arrived in Australia? What did you want for your child when you arrived in Australia? What are your hopes and dreams for yourself, your family, and your child now? When discussing safety planning, acknowledge that for families with a refugee background conception of safety might be restricted to fear of racial persecution and concerns for physical safety. Caregivers might not consider the young person to be at risk. Explore caregivers’ understanding of safety when trying to engage them in promoting the young person’s wellbeing.
Identifying supports in and outside the family system with the young person	Identify aspects of the distress the young person feels they can share with other family members. Explore what information they feel they can discuss with a family member and what they need to keep private. Questions might Include: Is there anyone in your family you can talk to about this? What aspects do you feel you can share, and which others do you need to keep private? Do you know of anyone in the family with a similar experience to yours? Identify supportive systems outside of the immediate family – e.g., education, friendship, peer support; school counselors; online communities’ support. Review potential barriers to accessing support and explore alternative pathways. In cases where there is support from family and caregivers, identify preferred ways to communicate gender within a cultural context.

Whilst there is no straightforward or linear action plan, these guidelines can contribute in formulating the individual care response to trans and gender diverse CALD youth. The fluctuating nature and rapid intensification of suicide related distress can make a care response dynamic. Regular team discussion, individual supervision and self-care are important.

Clinicians’ perspectives on challenges experienced by trans and gender diverse youth from CALD backgrounds

The CoP participants reflected that cultural conceptions on gender diversity add an extra layer of complexity to young people’s experience. The common perception in many CALD communities can be that a person identifying as trans or gender-diverse is immoral or sinful. Therefore, trans and gender diverse young people experience social stigma and the fear of standing exposed in their communities, bringing shame to their families and losing social support. It was observed by the CoP participants that being in Australia is not necessarily protective for this cohort. In the clinicians’ experience, there are narratives about people being placed in oppressive and potentially fatal situations by disclosing their gender diverse identities. This reality can inadvertently increase their sense of entrapment and hopelessness about the future, driving suicidal ideation and behavior.

Another driver of distress for individuals is cultural expectations around duty to family and community involvement. The CoP participants reflected that in their experience, CALD families and communities often do not share Western-based individually focused conceptualisations of mental health and wellbeing (including affirmative expression of gender and sexual Identities). Conversely, young patients are expected to be seen as participative community members. Whilst psychologically safe spaces to express gender identity and personal needs is not available, there is consistent pressure to conform to family expectations around duty of care for family members and fulfillment of heteronormative expectations around marriage and family arrangements.

The intersection between different cultural norms and expectations can therefore generate a deepening sense of alienation. In the CoP participants’ perpesctive, whilst for “mainstream” Australian young people, gender identity exploration might be a possibility, trans and gender diverse youth from CALD backgrounds would often feel unsafe to openly explore their gender identity due to a sense of taboo and fear of rejection. In many ways, perceiving peers having the opportunity to safely explore transgender or gender diverse identities might increase their perception of being on the margins and increase feelings of isolation. Similarly, trans and gender diverse young people from CALD backgrounds might perceive racially based discrimination from peers when engaging in mental health support services and environments inclusive of gender and sexual diversity. Such micro-aggressions can contribute to their distress and sense of entrapment as it adds an extra barrier to accessing social support.

CoP participants also reported the additional complexity of supporting trans and gender diverse youth from a refugee background. The response from frontline workers at the point of care often involves considering the influence of the trauma associated with fleeing one’s country and the journey to establish safety and settlement into Australia. Participants reflect that for many young patients and families of refugee background, the priority has been safety, sanctuary and survival. Families with a refugee background may require several years to feel safe and settled. Parents would prioritize providing for the child’s basic needs (e.g., providing medical assistance and access to schooling and education). Supporting the young person to explore their gender identity will therefore be out of the scope of these families’ priorities, restricting space and opportunity for the young person to disclose and discuss their distress and identify support persons.

Therefore, as practitioners the main question raised still remains: How to mitigate mental health and suicide related risk concern when there is no capacity to talk about it with a support person?

Practitioners’ supporting trans and gender diverse CALD youth in mental health and suicidal distress

Building trust and rapport – the role of “bearing witness” as a therapeutic strategy and tool to reduce inequality

The CoP participants reflected that when working with transgender and gender diverse youth from CALD backgrounds a waiting period is necessary for the development of trust between the young persons and practitioners. That is when trans and gender diverse youth might feel psychologically safe to disclose experiences of distress, including distress arising from exploring gender identification and expression.

The concept of bearing witness (Djkowich et al., 2019) was identified by the CoP participants as a helpful skill for practitioners in their daily practice. “Bearing witness” and validating experiences can bring relief in settings where immediate solutions to distress are not available. Participants reflected that for some young people deep listening, marked by periods of silence may link to being unable to talk about the causes of their emotional distress. An important recommendation herein is for workers not to limit their engagement to a mono-logic “problem-solving mode.” For young people experiencing such complex and multi-layered levels of experience, just creating an environment where they can feel safe to open up about their distress can be healing. Practitioners may say: “I am just here to listen,” right through to exploring the drivers of emotional distress. The idea being advanced here is to build trust and rapport with youth whom may have lost friendship and other supports usually available to their cisgender peers.

The concept of bearing witness has the additional potential to operate as a tool to reduce inequality in the therapeutic relationship between the person and practitioner. Practitioners may reflect on the professional and gendered position they hold and the opportunity to advocate for the rights of young patients who experience disadvantage and inequality. This can be done by bringing into conscious play the effects of social positioning and of their own situation in relationships of power and privilege and how these influence their ability to listen and authentically validate what is being said (Djkowich et al., 2019). The concept of “bearing witness” expands from passive listening to active efforts to shape clinical practice and engage ways to create difference that benefit patients (Code, 2010). At point of care this may create an opportunity to reduce explicit or implicit marginalization or power imbalance that might feature within the wider health system. Herein, we encourage clinicians to reflect on the position they are at and the opportunity they have to advocate for the rights of young people.

Encouraging culturally-meaningful expression of distress

CAMHS clinicians additionally identify the need to offer trans and gender diverse youth from CALD backgrounds the opportunity to espress their distress in a culturally-meaninful way, which requires cliniciains to reflect on their use of Western mental health terminology and conceptualization of mental distress. The role of the clinicians becomes to create understanding about what is happening for that person in specific detail, considering their social, cultural, and linguistic experiences. In other words, mental health workers must show respect and validation for the cultural diversity of this cohort. In the CoP participants perpective, young patients and their families might not feel comfortable enough to disclose what they are experiencing as they might fear prejudicial views of their lingusitic and cultural community. Clinicians can engage the young patients by naming—for example, that their own Western cultural perspective can impose challenges in understanding the young person’s distress and building psychological safety for them. Together, clinician and patient can explore together how relevant concepts are understood in the young person’s family and community—including distress, wellbeing, and gender identity exploration. The key principles can be grounded in ensuring that engagement and support strategies promote culturally meaningful expressions of mental distress, are tailored to young people of CALD background and involve exploring what young people themselves perceive to be enablers of success (Baker et al., 2016).

Offering flexibility and choice whilst sharing decision making around risk

CoP participants adopted the overall approach of being overt about confidentiality and the feasibility to support current and future decision making. Layers of complexity and risk contribute to young people feeling boxed in or trapped by current circumstances, and therefore an increase in self-harm and suicide ideation. Health workes must acknowledge that when managing risk, it might be necessary to disclose sensitive information to others. It is essential to clarify expectations and limits to confidentiality. For young people this can be perceived as intimidating, which can discourage disclosing of their experience of gender diversity. The young person must be offered choices on what they decide to talk about at a given moment. Participants reflected that it is a challenging process to negotiate about what can be disclosed to their families and select what matters can be managed at a later moment. Another challenge in this domain is that a Child Proctection notification must be raised once young people share their previous traumatic experiences As specified by section 31 of the Chidren and Young People (Safety) Act 2017—for example, the Australian legislation requires that different professional categories (e.g., teacher, police officers, health practitioners) must report that a child is, or may be, at risk if they formed this suspicion during the course of their employment. Therefore, there is a level of holding risk that health workers need to feel comfortable with.

An early key question for practitioners to consider is, “How is safety possible in the context of competing role expectations?” Trust is possibly the number one issue in these situations, as disclosure of such information can be risky for the young person. This is particularly true for newly arrived young people. Clinicians speak of their experience of young people having waited until they can communicate enough in English before they can disclose issues around gender exploration. Use of interpreters can complicate the matter as it might expose them in their communities. Clinicians are faced with complex questions: “How to manage the risk when there is no understanding of what is happening? How are we going to address it with the parents and include it in safety planning?” The CoP participants reflected that there is compelling need to further develop resources to adapt safety planning for these complex dynamics of risk and secrecy.

Engaging family in promoting safety for the young person

It can be psychologically unsafe within family and cultural groups for young people from CALD backgrounds to identify as trans or gender diverse, which emphasizes the importance of clinicians’ approach. CoP participants report that young people often choose not to disclose their gender identities to family. It is therefore necessary to discuss with the young patient their preferences on how to involve their family in care delivery. It is explained to the young person that there are limits to confidentiality in cases of immediate safety including suicide ideation and clinicians need to share responsibility not only with other professionals but with family members.

To establish a relationship of trust with parents and involve them in care, the first step is for clinicians to consider how suicide and mental health matters are understood and discussed within their cultures. Allowing caregivers to explore how these concepts are understood culturally, can assist the clinician to identify barriers and challenges to harness the supportive role that family can provide.

Following from this exploration, the clinician would validate the parents’ distress. Once more, CAMHS clinicians report it is helpful not to engage immediately in problem-solving or to present as a “know-it-all” clinician. Identifying with the parents what they are mostly concerned about and validating their experience helps to establish rapport. Caregivers and clinicians can build a shared understanding of what the family expects for the young person’s future and explore how to maximize the parents’ ability to provide support.

Identifying supports in and outside the family system with the young person

Whilst looking for and considering options for support, trans and gender diverse CALD youth would often turn to people that would just reinforce culturally driven rigid views about gender and the expectations of family to comply. Practitioners should give careful consideration to who will be the support person young patients engage with. Support at school or other mental health services may provide the best option. However, as highlighted above, youth might encounter ongoing barriers, such as racially based discrimination and lack of understanding of their experience from their cultural perspective. Additionally, it is important to help them to find an aspect of life they can engage with, which is fulfilling and can generate positive regard so trans and gender diverse CALD youth are not constantly thinking and feeling consumed by their stressors.

Implications for clinical practice

As trans and gender diverse CALD youth may avoid accessing mental health services due to fear of discrimination and re-victimization, the mental health and suicide prevention workforce must facilitate a culturally appropriate and safe service experience. In the perspective of the CoP participants, the practical actions identified herein are of designed and conceptualized to help reduce trans and gender diverse CALD youth’s distress and prevent suicide harm. The suicide of a young person is a devastating experience that impacts families for generations and affects the wider community to which they belong (Kõlves et al., 2019). Therefore, identiying ways of validating a person’s distress, facilitating developmental processes (e.g., identity exploration), and engaging family as a support toward a future-oriented agenda—the young person’s safety—are ways of reducing the onset and worsening of suicide related distress.

For trans and gender diverse CALD youth, perception of validation and openess toward one’s cultural experience of distress, might facilitate disclosure and processing of complex and painful emotions. Therefore, mental health practitioiners supporting CALD youth might benefit from training in cultural competence, which was reinforced in the perception of CoP participants. Moreover, the Australian National Committee on Mental Health and Suicide Prevention (Commonwealth of Australia, 2021) suggests that service delivery must be co-designed and co-delivered by people with lived experience and community understanding of the inequalities experienced by this group. The inclusion of lived experience voices in designing service response has the potential to contribute to the creation of a space where trans and gender diverse CALD youth feel safe to disclose their fears and distress and manage feelings of entrapment and hopelessness, thus overcoming suicidal thoughts and engaging in a life worth-living.

We are aware of the limitations of the recommendations herein presented, which were based on the first-hand experience of mental health professionals working with trans and gender diverse CALD youth and could be therefore biased. Further investigation on the applicability of the practical actions herein presented and the potential impact on suicide prevention among trans and gender diverse CALD youth is recommended. The recommendations presented may be limited somewhat to mental health crisis and suicidal distress in the context of mental health care service delivery. Further research into effective responses in other contexts (e.g., emergency departments, community settings, private clinical settings) may bring additional information of different strategies and approaches.

Conclusions

CoP participants identified that the intersectionality between identification as trans and gender diverse and CALD origin adds particular layers of circumstance and complexity to mental health care delivery. Participants stressed that addressing the multifaceted layers of risk starts by allowing for the development of rapport and a therapeutic relationship of trust between clinician, young patient and their families. Other key practical actions identified involve validating the experience of this group, clear communication over limits to confidentiality, offering flexibility and choice around risk engagement and management decisions whenever possible, and discussing with both the young person and family the best ways to potentialize the supportive role of the family, whilst identifying supports outside of the immediate family system.

Authors’ contributions

Made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data; DM, MM, AM, DG, HT, RS NP. Involved in drafting the manuscript or revising it critically for important intellectual content; DM, MM, AM, DG, HT, RS NP. Given final approval of the version to be published. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content; DM, MM, AM, DG, HT, RS NP. Agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. DM, MM, AM, DG, HT, RS NP.

Ethics statement

Ethics committee clearance is not applicable to this article as no datasets were generated or analysed during the writing of the paper.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The original data contributions presented in the paper are included in the article material, further inquiries can be directed to the corresponding author.

Additional information

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.