Inhibition of NO production in LPS-activated RAW 264.7 cells of stilbenes isolated from Gnetum latifolium

Nguyen Thi Thu Hoa1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 10000, Vietnam;3 Hanoi University of Industry, Cau Dien, Nam Tu Liem, Hanoi, 10000, Vietnam

Ba Thi Cham1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Le Thi Hong Nhung3 Hanoi University of Industry, Cau Dien, Nam Tu Liem, Hanoi, 10000, Vietnam

Nguyen Thi Kim Anh4 National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, 10072, Vietnam

Nguyen Tuan Hiep1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 10000, Vietnam;4 National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, 10072, Vietnam

Nguyen Thi Hoang Anh1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Trinh Thi Thuy1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Domenico V Delfino5 Master in Musculoskeletal and Rheumatology Physiotherapy, Department of Medicine and Surgery, University of Perugia, 06132, Italy

Nguyen Thi Thuy Linh1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, VietnamCorrespondence[email protected]

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Abstract

The phytochemical investigation of Gnetum latifolium var. funiculare Markgr. resulted in the isolation of five compounds (1-5). Their structures were determined as bisisorhapotingenin A (1), genetifolin E (2), genetifolin K (3), piceid (4), and isorhapontin (5) based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. All of these five isolated compounds were evaluated for their inhibition effect on lipopolysaccharide (LPS)- induced nitric oxide (NO) production in RAW264.7 macrophages. Among them, two compounds (1 and 3) showed moderate effect on NO production inhibition in LPS-activated RAW264.7 cells with the IC₅₀ values of 53.80 and 93.94 μM, respectively.

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Inhibition of NO production in LPS-activated RAW 264.7 cells of stilbenes isolated from Gnetum latifolium

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Inhibition of NO production in LPS-activated RAW 264.7 cells of stilbenes isolated from Gnetum latifolium

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